Increases in Spinal Cerebrospinal Fluid Potassium Concentration Do Not Increase Isoflurane Minimum Alveolar Concentration in Rats
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چکیده
منابع مشابه
Inhibition of glutamate transporters increases the minimum alveolar concentration for isoflurane in rats.
BACKGROUND Glutamate transporters [also named excitatory amino acid transporters (EAATs)] bind and take up extracellular glutamate, a major excitatory neurotransmitter, and can regulate glutamatergic neurotransmission in synapses. As anaesthesia is proposed to be induced by enhancing inhibitory neurotransmission, inhibiting excitatory neurotransmission, or both we hypothesize that inhibition of...
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Nimodipine is a calcium antagonist that binds with high affinity to neuronal membranes. It is a potent cerebrovasodilator and has been demonstrated also to affect neurotransmitter synthesis and release. Because patients undergoing surgery for intracranial aneurysms are frequently receiving nimodipine, the authors determined the MAC of isoflurane in six dogs before and during three infusion dose...
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It has been suggested previously that tramadol increases central nervous system activity and 'lightens' anaesthesia with volatile agents. We assessed the effects of tramadol on the minimum alveolar concentration (MAC) of isoflurane in 56 Wistar rats, instrumented chronically with an arterial and central venous catheter. The MAC of isoflurane was determined using the tail clamp method under thre...
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UNLABELLED Several reports suggest that clinically used concentrations of inhaled anesthetics can increase conductance through noninactivating potassium channels and that the resulting hyperpolarization might decrease excitability, thereby leading to the anesthetic state. We speculated that animals deficient in such potassium channels might be resistant to the effects of anesthetics. Thus, in t...
متن کاملMinimum alveolar concentration: A reconsideration
Minimum alveolar concentration (MAC), served as the vital concept for standard measure of potency for inhaled volatile anesthetic agents, has been employed in anesthetic practice for more than 50 years. A re-consideration in the connotation and influence factors on MAC is introduced in this article. MAC actually indicates “median effective dose (ED50) for immobility”, but it is at least not com...
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ژورنال
عنوان ژورنال: Anesthesia & Analgesia
سال: 2008
ISSN: 0003-2999
DOI: 10.1213/ane.0b013e3181815f2b